75 



For the certain demonstration of Pfeiffer's bacillus therefore, 

 cultivation must be insisted upon, but direct microscopy may 

 in many ways supplement it. 



By cultivation, Pfeiffer's bacillus was found in 01 (38%) 

 of the 162 sputa, that is to say in 34 (35<y ) of the 98 patients. 



In the following table will be found the number of po- 

 sitive and negative findings which were made on the 1st., 

 2nd., 3rd., etc day of the disease. 



Day of Disease + Day of Disease + Day of Disease -|" 



11 16 4 35 1 



2 2 4 17 4 36 ; 1 • 



3 7 3 18 3 37 -1 



, 4 . , , 1 5 19 1 38 .. 12 



5 3 6 20 11 39 1 



6 6 9 22 2 2 45 1 



7 2 4 23 1 46 " 1 



8 2 7 24 12 - -47 1 



9 19 25 2 1 51 _ ... 1 



10 3 4 27 .1 . 52 r 1 



11 14 30 2 54 1 



12 3 5 31 12 59' 'l 



14 2 32 1 73 1 



15 3 1 34 11 80 1 



The next table records the occurrence of Pfeiffer's bacillus 

 in the various stages of the disease. 



' .' + ° 



1. Uncomplicated cases, in the febrile stage 11 12 



2. „ „. after temperature had become normal ., 3 7 



3. Cases where pneumonia developed later 2 1 



4. Pneumonic cases before temperature had fallen to normal ........ 30 55 



5. „ „ after „ „ „ „ „ . 6 21 



All the 162 examinations do not appear in the table, because, 

 in the case of 5 patients, in 'whom Pfeiffer's bacillus was found 

 on the first examination, I undertook a series of new tests. These 

 repeated examinations are left out because the few patients would 

 otherwise have too great weight in comparison with the other ma- 

 terial. 



We see that Pfeiffer's bacillus is encountered with great 

 frequency in the early stages of the disease but it may quite 

 likely be found at a much later date and even after the fever 

 is over. It will also be observed that it is very common to 



