164 Sylvius and his Pupils. [lect. 



" very thirsty, drinking largely of water in proportion to the 

 " discharge of urine." But as Brunner observes, the acute 

 Malpighi has noticed a similar result after ligature of the 

 vessels of the spleen only. These are Malpighi's words : 



" In a dog of as yet tender years a wound was made in the 

 " left hypochondrium, and the blood vessels of the protruding 

 " spleen and attached omentum were ligatured with a thread 

 " close to the hilus of the spleen ; everything was presently re- 

 " placed in its former position, the peritoneum and the muscles 

 " were sutured and the skin loosely united. After the lapse of a 

 " few days the wound had healed. After some weeks the animal 

 " was strong enough to perform with enjoyment all its proper 

 u functions ; so long as it lived no trace of any interference with 

 '* health could be observed. Having become more hungry than 

 " before, it took its meals eagerly, devouring bones and food of 

 "all kinds. One thing only I observed, namely that it made 

 "water abundantly and most frequently, in fact continually. 

 "Though all dogs are continually doing this, it seemed in 

 " this respect to outdo all its fellows. Its habit of body was 

 " in every respect sound ; indeed it became fat, and in other 

 "respects, in quickness and alacrity it equalled its fellows." 



Post-mortem examination shewed an atrophy of the spleen, 

 but hardly any other abnormality. 



In another experiment, in which the pancreas alone was 

 removed, Brunner observes : " I had bought the animal from a 

 " butcher, and after the operation it also was hungry. It was 

 " continually going to its old master's shop and stealing pieces 

 " of meat. Indeed it carried on this game to such an extent 

 " that the butcher came to me and demanded that it should be 

 " killed. This however I put off doing since I w 7 anted to enjoy 

 " for some time longer such a pleasant experience * as the 

 "animal's condition afforded me." In another experiment too 

 the animal was particularly hungry and greedy; but in this 

 case it is especially noted that there was no other symptom, 

 "he was not more thirsty than before the operation." 



With Brunner and Peyer's discovery, the short-lived glory 

 of the pancreatic juice, raised up for it by Sylvius and De Graaf, 

 passed away. The minds of physiologists went back to the 



