EXAMINATION OF HYDROGEN DIOXID SOLUTIONS. 11 



results were not conclusive. Caffein was found in several packages 

 of one brand. 



ANALYTICAL RESULTS. 



The analytical results obtained in this investigation are given in 

 the table on pages 12 and 13, together with a statement of the loss in 

 hydrogen dioxid in six months and in one year on each sample. 



INVESTIGATION MADE IN NASHVILLE. 



All of the samples were examined as to purity, quality, and 

 strength, by the pharmacopreial methods. The investigation cov- 

 ered two series, one begun in October, 1907, and the other in Decem- 

 ber of the same year. The acetanilid was extracted by means of 

 chloroform, it having been shown that less than one-fiftieth of a 

 grain could be detected by the phenol-isocyanid reaction. The 

 several samples were reexamined at the intervals of time indicated 

 in the table on page 14. 



COMMENTS BY MANUFACTURERS. 



The results of the analyses of the several brands were referred to 

 the respective manufacturers, with the following results: No replies 

 were received from the Clarion Chemical Co., Eimer & Amend, 

 Larkin & Scheffer, Lehn & Fink, Matz & Cohen, and Squibb & Sons. 

 The following firms acknowledged receipt of results but offered no 

 criticisms, and their replies are therefore not further considered: 

 American Druggists' Syndicate, Otis Clapp & Son, Harvey Co., 

 Mulford & Co., Norwich Pharmacal Co., H. K. Wampole, William R. 

 Warner, Tilden Co., William S. Merrell, Meyer Bros., Towns & 

 James, and Powers, Weightman, Rosengarten Co. 



The comments of the manufacturers who responded are as follows: 



ALBANY CHEMICAL Co. 



We venture to say that our samples make a very good showing, in view of the fact 

 that hydrogen peroxid loses strength rapidly during the first few months after it has 

 been prepared. What is your experience in this direction? 



Acidity . . . The quantity present, found by you, apparently coincides with the 

 findings of our laboratory for several years back, that is to say, our H 2 O 2 shows about 

 50 per cent better than the U. S. P. allows. The same is the case with the solids. 



Comment by authors. It is to be noted that the results show that 

 the acidity is excessive. 



BRUEN, RITCHEY & Co. 



Your letter of the 16th to hand and in reply would say the hydrogen peroxid we 

 supply conforms to the U. S. P., and the test as outlined by you fyears this out with 

 the exception of the test for solids, as the U. S. P. allows only 0.030, whereas you make 

 it much over. 



