148 MAN --AN ADAPTIVE MECHANISM 



patients or animals which have undergone extensive 

 operations under inhalation anesthesia. 



A comparison of the effects of adrenin with those 

 of iodized protein or iodin makes clear at once which is 

 the primary and which the secondary glandular reac- 

 tion. Adrenin, if exposed to the air, is oxidized in a 

 few minutes ; in the blood it is oxidized as quickly. 

 Adrenin acts almost instantaneously, and its effects 

 disappear almost as quickly. On the other hand iodized 

 protein and iodin act more slowly. The effects of a 

 single dose of iodin are not seen for a number of hours 

 - but continue for a day or more even as do emo- 

 tions. There is no evidence that adrenin is stored in 

 bulk in the adrenals as iodin is stored in the thyroid, 

 but there is evidence that adrenin is fabricated as 

 needed. It requires more tirfie to fabricate thyreo-iodin. 

 There is evidence, however, that with the ebb and 

 flow of emotion there is an- ebb and flow in the store 

 of iodin in the thyroid. These facts make it appear 

 that the secretion of the thyroid determines the key 

 in which adrenin plays the itune of life. 



Relation of the Liver to Distance Ceptor Stimulation 

 In addition to the experimental and clinical evidence 

 that chemical or histologic changes are produced by 

 emotion in the brain, thyroid and adrenals, we have 

 evidence that as a result of the transformation 

 of energy in emotion, histologic changes are pro- 

 duced in the liver also. As a result of any in- 

 creased energy transformation in the body there 

 is an increased formation of acid by-products, with a 

 corresponding increase in the activity of the mechanism 



