180 MAN --AN ADAPTIVE MECHANISM 



transformation of energy, the brain, the adrenals and 

 the liver bear their portion of the stress of life take 

 their portion of the work of producing activity, and also, 

 as we shall see later, the burden of repairing the effects 

 of activity. 



Functional Changes in the Adrenals in Relation to 

 Transformation of Energy 



The identical functional changes in the adrenals 

 under activation are as significant as are the identi- 

 cal histologic changes in the brain, the adrenals 

 and the liver. In our experiments the types of ac- 

 tivation that produced histologic changes in the brain, 

 the adrenals and the liver produced an increased out- 

 put of adrenin. The functional activity of the adrenals 

 was determined (1) by the biologic test 1 and (2) by the 

 determination of the H-ion concentration of the blood 

 in the adrenal veins before and after activation. 



In examinations of the blood of sixty-six animals 

 subjected to rage, fear, anaphylaxis, injections of indol, 

 skatol, leucin, creatin, toxins of diphtheria, colon 

 bacilli, foreign proteins and strychnin, the biologic test 

 for adrenin was positive. (Figs. 38, 39.) In brief, the 

 agencies which caused histologic changes in the brain, 

 the liver and the adrenals, with the single exception of 

 traumatism under anesthesia, caused an increased func- 

 tional activity of the adrenals. 



H-ion concentration tests showed that the blood in 

 the adrenal veins was more alkaline than the blood 

 from the brain, muscles, pancreas, liver, thyroid, 



1 Inhibition of intestinal muscle. 



