ACUTE I NTt>\]< \TION--RABBITS. 23 



Rabbit 341. White and brown. Weight, 1,450 grams. Diet, oats 



M;in-h :><>: :i.L'o i- in ., 20 cc 2 per cent caffein (270 rag per kilo) injected subcu- 

 taneously in back; 4.40 p. in., found in dying condition, had convulsions; 4.45 p. m., 

 dead. 

 Rabbit 326. White, male. Weight, 1,645 grams. Diet, oats, March 8 to 16. 



March 16, 1910: 12 noon, 20 cc 2 per cent caffein (243 mg per kilo) injected subcu 

 taneously in the back; 2 p. m., tremors marked, hypersensitive, started to run when 

 put on floor; rabbit was not handled any more than was required for his removal from 

 and return to cage. 



March 17: 9.30 a. m., tremors still present and marked, otherwise general condition 

 good; no other symptoms. 



March 18: 9.30 a. m., no appetite, tremors still present, general condition poor; 

 died about 2 p. m. 

 Rabbit 235. Belgian hare, male. Weight, 1,870 grams. Diet, carrots, November 2 to 9. 



November 10: 11.05 a. m., 25 cc 2 per cent caffein (267 mg per kilo) injected subcu- 

 taneously; reflexes increased and tremors, but no tetanus observed; found dead next 

 morning. 



Rabbit S16. Belgian hare, female. Weight, 860 grams. Diet, oats, March 8 to 16. 



March 16, 1910: 11.40 a. m., 12 cc 2 per cent caffein (267 mg per kilo) injected sub- 

 cutaneously in the back; 2.15 p. m., reflexes somewhat increased, but not markedly 

 so; walked when put on floor; gait clumsy and slow; tremors of head observed; 2.35 

 p. m., rabbit lying in his cage, posterior extremities extended and rigid, anterior 

 extremities flexed, head retracted; is still breathing; occasional spasms observed. 

 Rabbit died at 3 p. m. Autopsy: No lesion at point of injection in dorsal spinal 

 muscles; liver and spleen engorged; intestines injected; other organs apparently 

 normal. 

 Rabbit 395. Belgian hare, male. Weight, 1,410 grams. 



August 18: 1 p. m., 20 cc 2 per cent caffein (283 mg per kilo) injected subcutaneously 

 in the back; 4 p. m., reflexes markedly increased; 5 p. m., reflexes about the same, 

 but no tetanus. 



August 19, 9.15 a. m.: Reflexes increased markedly. 



August 21, weight, 1,215 grams. Given 275 mg per kilo of caffein; no symptoms 

 observed. 



August 23, found dead. Autopsy: Liver greatly engorged; stomach fairly well dis- 

 tended and mucous membrane in a slightly inflammatory condition; contents of 

 small intestine liquid in nature, but walls of same appeared normal; other organs 

 normal in appearance. 

 Rabbit 396. Belgian hare, female. Weight, 1,475 grams. Diet, oats. 



August 18: 1 p. m., 20 cc 2 per cent caffein (272 mg per kilo) injected subcutaneously 

 in the back ; 4p.m., reflexes increased markedly; 5p.m., reflexes increased markedly 

 but no tetanus. 



August 15: 10.30 a. m., reflexes still increased very markedly; rabbit jumps when 

 touched. 



August 21: Weight, 1,245 grams. Injected subcmtaneously 275 mg of caffein per 

 kilo; reflexes increased, posterior extremities stiff over hour later. 



August 22: 9 a. m., found dead. Autopsy: Thoracic organs normal in appearance; 

 stomach distended and mucous membrane affected with a catarrhal inflammation; 

 contents of stomach were covered with a shiny mucus; contents of small intestine 

 liquid in nature and bile stained; liver showed a coccidial infestation; kidneys and 

 spleen normal in appearance. 

 Rabbit 397. Belgian hare, male. Weight, 1,375 grams. Diet, oats. 



August 19: 10.30 a. m., 20 cc 2 per cent caffein (290 mg per kilo) injected subcu 

 taneously in the back. 



August 22: 9 a. m., found dead. Autopsy: Stomach distended with ingesta; 

 mucous membrane exhibited a catarrhal inflammation with excessive secretions; 

 major portion of intestines showed a condition similar to that of stomach, contents 

 consisting mainly of a shiny mucus; liver enlarged; other organs apparently normal. 

 Rabbit 398, Belgian hare, female. Weight, 1,570 grams. Diet, oats. 



August 19: 10.30 a. m., 23 cc 2 per cent caffein (293 mg per kilo) injected subcutane- 

 ously in the back; 4 p. m., found dead. Autopsy: Thoracic organs seemingly normal; 

 mucous membrane of stomach exhibited a catarrhal inflammation generally; large 

 intestines somewhat impacted but walls appeared normal; other organs normal. 

 Rabbit 399, Belgian hare, male. Weight, 1,725 grams. Diet, oats. 



August 19: 10.30 a. m., 26 cc 2 per cent caffein (300 mg per kilo) injected subcutane- 

 ously in the back; found dead at 4.30 p. m. Autopsy: Lungs slightly congested; liver 



