ACUTE INTOXICATION RABBITS. 



41 



more rapidly. It is quite probable, therefore, that a much slower rate of injection 

 may lessen considerably the toxicity of caffein. 



From the results of the experiments by intravenous injection summarized in the 

 table, it appears that the minimum toxic dose for rabbits of a 2 per cent caffein solu- 

 tion, injected at the rate of 1 cc per minute, is about 50 mg per kilo. Twice the dose 

 induces severe symptoms and may be fatal; 160 mg per kilo are surely fatal. If the 

 rate of injection is diminished, the toxicity of caffein is lessened, but this effect is 

 not marked unless the injections are very slow. Dilution of the caffein solution sup- 

 presses to some extent the nervous symptoms, but the toxicity, on the contrary, seems 

 to be increased. 



TABLE 5. Intravenous injections. 



SERIES A. 



SERIES B, GROUP I. 



SERIES B, GROUP II. 



SERIES C. 



SERIES D. 



SERIES E. 



