CONTENTS. 



Page. 



Introduction 5 



Historical review of the literature on the toxicity of caffein 9 



Acute caffein intoxication 18 



Experiments on rabbits 18 



Subcutaneous injection 18 



Administration by mouth 2G 



Injection into the peritoneal cavity 28 



Intramuscular injection , 33 



Intravenous injection 37 



Summary 42 



Experiments on guinea pigs 43 



Subcutaneous injection 43 



Injection into the peritoneal cavity 47 



Administration by mouth . . 49 



Summary 52 



Experiments on cats 53 



Subcutaneous injection 53 



Injection into the peritoneal cavity 56 



Administration by mouth 57 



Summary 59 



Experiments on dogs 60 



Administration by mouth 60 



Subcutaneous injection 60 



Experiments on puppies 61 



Summary 62 



Chronic caffein intoxication 63 



Experiments on rabbits 63 



Experiments on dogs 75 



Discussion of results 91 



General summary and conclusions 95 



Bibliography 97 



3 



