LETTER OF TRANSMITTAL 



U. S. DEPARTMENT OF AGRICULTURE, 



BUREAU OF CHEMISTRY, 

 Washington, D. C., November 14, 1911. 



SIR: I have the honor to submit for your approval a manuscript 

 on the toxicity of caffein, which is the first of a series of reports to 

 be made by Dr. Salant on the pharmacology of this drug; the con- 

 clusions here reported are, therefore, in some particulars to be 

 regarded as tentative. The data obtained are primarily of use in the 

 execution of the food and drugs act, but are capable of much broader 

 application. 



Acknowledgment is made of the assistance rendered by Dr. John 

 R. Mohler, Chief of the Pathological Division, Bureau of Animal 

 Industry, and his assistants, in performing the autopsies recorded in 

 this report. I recommend the publication of the manuscript as 

 Bulletin No. 148 of the Bureau of Chemistry. 

 Respectfully, 



H. W. WILEY, Chief. 

 Hon. JAMES WILSON, 



Secretary of Agriculture. 

 2 



THIS PUBLICATION may be pro- 

 cured from the Superintendent of 

 Documents, Government Printing Office 

 Washington, D. C., at 15 cents per copy 



