62 



THE TOXICITY OF CAFFEIN. 



that the symptoms in older subjects when given toxic doses of caffein set in rather 

 abruptly and ended in instantaneous death. We failed to observe this phenomenon 

 after the administration of large amounts of caffein to very young dogs, in which tonic 

 and clonic convulsions alternating with paresis were observed. These symptoms set 

 in rather gradually and lasted several hours (see experiment No. 8), resembling the 

 rabbit in this regard. 



SUMMARY. 



The toxicity of caffein for adult dogs is about the same, whether given by mouth 

 or injected subcutaneously. The resistance of puppies to caffein is much greater than 

 that of adults. 



TABLE 12. Administration by mouth; dogs. (Series A.) 



TABLE 13. Subcutaneous injection; dogs. (Series B.) 



TABLE 14. Administration by mouth to puppies. (Series C.) 



