64 



THE TOXICITY OF CAFFEIN. 



'Rabbit 173. Carrots were fed from October 1 to 18 and oats for the remainder of the experi- 

 ment. 



October 21: Paralysis of posterior extremities. 



October 22: 9 a. m., found dead. 



The urine was examined before and after the administration of caffein. No symp- 

 toms were observed after the administration of caffein (5 doses in 11 days), nor was 

 albumen or sugar found in the urine after any of the experiments on this rabbit. 

 Autopsy: Pyloric mucosa exhibited several ulcers: small intestines showed slight 

 inflammation; liver deeply congested; kidneys showed marked inflammation of cortex; 

 other organs practically normal. 



Rabbit 181. Diet, carrots September 29-October 17, then oats. 



Rabbit was markedly emaciated and weak, 

 urine as a result of caffein feeding. 



Rabbit 182. Diet of carrots from September 29. 

 Received caffein subcutaneously as follows: 



No albumen or sugar found in the 



October 12: 11 a. m., 23 hours after caffein was given, convulsions with recovery; 

 rabbit died at 1.30 p. m. No sugar was found in the urine at any time after the 

 administration of caffein. Albumen was present only in one specimen. 



Rabbit 183. Diet of carrots from September 29. 

 Received caffein subcutaneously as follows: 



October 12: 9 a. m., found dead, 

 sample contained sugar. 



No albumen was found in the urine. Only one 



