70 



THE TOXICITY OF CAFFEIN. 



on a diet of carrots or of oats. These results also show that caffein'is much more toxic 

 with repeated dosage. As stated in the historical part of this bulletin the same view 

 was held by Goure witch. 28 



Rabbit 386. Belgian female. 

 Given 1 cc of 1 per cent caffein for each 100 grams, through stomach tube. 



August 20: Found dead 9 a. m. Autopsy: Lungs slightly congested; liver engorged 

 and friable; gall cyst well filled. 

 Rabbit S89. Black male. 



Given 1 cc of 1 per cent caffein for each 100 grams, through stomach tube. 



August 19: Found dead 9 a. m. Autopsy: Lungs severely congested and partially 

 hepatized; liver was engorged; other organs appeared normal. 

 Rabbit 382 . Belgian female . 



On August 17 weighed 1,035 grams; received 1 cc of 1 per cent caffein for each 100 

 grams; 10 cc of 1 per cent caffein given in all. 



August 18: Found dead 9 a. m. Autopsy: Lungs congested and hepatized; liver 

 engorged; stomach showed numerous petechial hemorrhages on mucosa; kidneys 

 slightly congested; intestines appeared normal. 

 Rabbit S85. Belgian female. 



Given 1 cc of 1 per cent caffein for each 100 grams, through stomach tube. 



August 22: Found dead 9 a. m. Autopsy: Lungs exhibited pneumonic lesions, 

 with inflammation of adjacent pleura; a nbro-plastic exudate present around lung; 

 liver showed a coccidial infestation; stomach distended with ingesta; mucous mem- 

 brane characterized by a catarrhal inflammation; contents of small intestine liquid 

 in nature and bile stained; large intestine somewhat impacted; liver and kidneys 

 seemingly normal. 



