CHANGES IN NON-PREGNANT UTERUS 91 



only involves certain portions of the superficial epithelium. Van 

 Herwerden states that the menstrual changes are less marked in 

 the region of the fundus uteri. 



The chief differences between van Herwerden's account and that 

 of Heape are as follows : 



According to the former the stroma cells increase mitotically, 

 and not by simple division or fragmentation as supposed by 

 Heape. 



The epithelium is described as being renewed from the glandular 

 epithelium in Cercocebus, and not in part from the subjacent stroma, 

 as it is said to do in Semnopithecus and Macacus. 



Van Herwerden says that, so far as was observed, the walls of 

 new vessels were not formed during recuperation from stroma cells 

 as has been described by Heape. 



Van Herwerden states that Cercocebus may experience oestrus 

 after menstruation is over. Presumably, therefore, cestrus occurs 

 contemporaneously with the recuperation process in the uterus. 



THE CYCLE IN LEMUKS 



As already mentioned, Stratz l has called attention to the pro- 

 cestrous changes which take place in the uterus of Tarsius spectrum, 

 but the process has been studied more closely by van Herwerden. 2 

 This author describes the following changes : 



(1) There is a swelling of the glands which is closely followed 

 by mitotic division among a large number of the epithelial cells. 

 Hypertemia then sets in; but the congestion is localised to certain 

 places, and is not diffused over the entire mucous membrane. 

 Afterwards blood becomes extravasated in the stroma tissue, the 

 corpuscles being aggregated in the more superficial parts that is 

 to say, in the vicinity of the epithelium. It was noticed that 

 certain corpuscles were taken up by leucocytes, and transported to 

 the uterine cavity. Others were carried along in close association 

 with epithelial cells, both from the superficial layer and from the 

 glands. 



It would appear that destruction of the epithelium does not 

 occur to any extent, and that the bleeding is not severe. This would 

 seem to constitute the chief difference between the prooestrous 

 changes in Tarsius, and the corresponding changes in monkeys. 



The periodicity of the sexual phenomena in Tarsius spectrum has 

 already been referred to. 



1 Stratz, Der geschlechtsreife Saugethiereierstocl; Haag, 1898. 



2 Van Herwerden, loc. dt. 



