94 INFECTION AND IMMUNITY 



lodgment through some superficial wound or abra- 

 sion, or possibly through the bites of insects, and it 

 first invades the lymphatics, producing inflammation 

 of the nearest lymphatic glands. General invasion 

 of the blood appears, from recent investigations, to 

 be a secondary phenomenon which only occurs in 

 very severe and usually fatal cases. 



The pulmonic form of the disease, which was so 

 prominent in the epidemic known as black death, is 

 extremely fatal and is known to occur at the present 

 day. 



Bubonic plague continued to prevail in various parts 

 of Europe at the end of the sixteenth century, and 

 early in the seventeenth century (1603) an epidemic 

 occurred in London which caused the death of 38,000 

 of its inhabitants. It continued to prevail in this city 

 and in various parts of England, Holland, and Ger- 

 many, and six years later caused a mortality of 1 1,785 

 in the city of London. During the year 1603 a most 

 disastrous epidemic occurred in Egypt, which is said 

 to have caused a mortality of at least a million. After 

 an interval of ten or fifteen years, during which there 

 was a marked diminution in the number of cases and 

 the extent of its distribution in European countries, 

 it again obtained wide prevalence during the year 

 1620 and subsequently, especially in Germany, Hol- 

 land, and England. The epidemic in the city of 



