CATTLE PLAGUE. 



days afterwards, a small, slightly elevated, hard pimple was felt 

 and >een on the site of tin' puncture. This gradually advanced 

 till the ninth day of the puncture, the fourth from papula tion, 

 when the enlargement became distinctly vesicular. At that time 

 there were hut slight constitutional symptoms. On the next day, 

 tin- tenth from the receipt of the puncture, the fifth from papulation, 

 and the x'cnnd from vesiculation, Mr. Hancock consulted Mr. Rayner, 

 of Uxl -ridge, who, on seeing the hand, inquired if the patient had 

 heeu handling the udder of a cow, as he thought he could recognise 

 a cow-pox vesicle of the ninth day. The vesicle was distended 

 with thin lymph, its margin elevated and slightly brown, its centre 

 depressed and brownish, and the whole surrounded with a large 

 bright red areola. There was then considerable tumefaction extend- 

 ing from the knuckles to above the wrist. The absorbent ve>-< -'t- 

 were considerably inflamed, and, like the axillary glands, were tender 

 and painful; the pulse, naturally slow, was accelerated; there was 

 much pain in the back and limbs, severe distracting headache, etc. ; 

 all of which symptoms continued to increase during the two following 

 <lays. At the end of that time the diffused areola had extended as 

 far as the elbow. Fifteen days after the puncture, and ten days after 

 papulatioii, the local inflammation and constitutional symptoms had 

 partially subsided. The vesicle contained a rather turbid brownish 

 fluid, and there were present all the indications of a declining vaccine 

 vesicle. 



Murchisnii also saw and described the case, and gave practically 

 the same account of it. He pointed out that the appearances and 

 the entire history were \-ry different from the results of a poisoned 

 wound, but coincided with the appearances seen after vaccination. 



In 1832 Macpherson, in Bengal, inoculated eleven native children 

 with cattle-plague cru>t>. There was no result in six, others 

 suffered from local inflammation, and in one a v->icl- formed. 

 \Vith lymph from this vesicle other children were inoculated. The 

 results in all were similar in appearance to those of vaccination. 

 Two children were subsequently inoculated with human variola, and 

 were said to be protected. 



In 1834 Macpherson's example was followed by Mr. Fun ell 

 in ASM m. Furnell inoculated four children with cattle-plague 

 crusts without result, but hi> awtttnl sucn-eded with crusts taken 

 from the back and abdomen of the di>ens-d cattle, and carried on 

 the lymph from child to child. In one case there was a general 

 eruption. Furnell inoculated his own child from one of the native 

 children: a copious eruption followed, and the child died. Furnell 



