322 INFECTIVE DISEASES. 



crusts from the cow's teats, with the result that from both sources 

 an eruption was produced, which in appearance and course was like 

 vaccinia. With lymph from one of the calves, a public vaccinator 

 inoculated a number of infants, and fine vesicles developed, indis- 

 tinguishable from vaccinia. 



In 1894 Mr. Bucknill met with a case in a milkman. He had 

 been milking a cow affected with cow-pox, and on the ninth day after 

 exposure to infection, and the seventh day after the eruption of the 

 first papule, there were three pocks on the fore-arm. The pocks 

 were elevated, circular, and umbilicated, with a dull, creamy-white 

 ring at the circumference, and there was well-marked induration 

 and extensive areola. There were four excellent marks of primary 

 vaccination. The vesicles contained clear lymph, and re-inoculation 

 of the arm failed to take. An attempt to re-vaccinate the man 

 with current calf lymph produced only topical irritation. 



INOCULATED COW-POX. 



Natural or Virulent Lymph. Severe symptoms are not limited to 

 milkers casually infected from the cow. Under certain conditions, 

 artificial inoculation of fresh virus from the cow reproduces the 

 disease without any mitigation. Thus, in Jenner's cases : 



" James Phipps. The incisions assumed at their edges rather a 

 darker hue than in variolous inoculation, and the efflorescence around 

 them took on more of an erysipelatous look. They terminated in 

 scabs and subsequent eschars. 



" Susan Phipps was inoculated from the cow by inserting matter 

 into a superficial scratch on December 2nd. The child's arm now 

 showed a disposition to scab, and remained nearly stationary for 

 two or three days, when it began to run into an ulcerous state, 

 and then commenced a febrile indisposition, accompanied with an 

 increase of axillary tumour. The ulcer continued spreading near 

 a week, during which the child continued ill, when it increased to 

 a size nearly as large as a shilling. It began now to discharge pus ; 

 granulations sprung up, and it healed." 



Jenner's lymph was employed by Mr. Cline with similar results. 



" The child sickened on the seventh day, and the fever, which 

 was moderate, subsided on the eleventh. . . . The ulcer was not 

 large enough to contain a pea." 



Precisely similar experiences have since been encountered, in the 

 early removes of fresh stocks of virulent lymph. Bousquet in France, 

 in his first trials with a new lymph, in 1836, made three punctures, 

 but he had soon to abandon this practice, because the intensity 



