INOCULATED COW-POX. 



of the inflammation was sometimes so great tli.-it it >pread over the 

 entire aim as far as the glands of the axilla. In one case, tin- 

 vehicle* were enormou>. and the inflammation so violent, that bath>. 

 poult ice>. fomentations, and antiphlogistic diet scarcely sufficed 

 to reduce it. The crusts when they fell off left ulcerations which 

 were very >low to undergo cicatrisation. In some cases, the vesicles 

 which resulted hollowed out the skin so deeply that they left regular 

 holes. 



In the following year Estlin, in England, started a stock of fresh 

 \arrine virus from the cow, and found on inoculating children that 

 the new lymph was extremely active. 



In 52 the disease was regular, 

 ., 1 severe erysipelas, 



,, 4 er ythematous eruptions of a violent character, 

 ,, 2 highly inflamed ulcerated arms, 

 ,, 1 no effect after twice vaccinating, 

 8 result unknown ; supposed to have been favourable. 



68 



Cultivated or Attenuated Lymph. When cow-pox lymph has 

 been mitigated by successive transmission through the human subject, 

 or by cultivation on the belly of the calf, with careful selection 

 of vesicles, it will produce effects which are as follows : About 

 the end of the second day after insertion, or early on the third day, 

 a slight papular elevation is noticeable. By the fifth or sixth day, 

 it has become a distinct vesicle, of a bluish-white colour, with raised 

 margin and central cup- like depression. By the eighth day, the 

 vesicle is perfect. It is circular, pearl -coloured, distended with clear 

 lymph, and the central depression is well marked. On the same day, 

 <>r a little earlier, the areola begins to appear, and gradually extends 

 to a diameter of from one to three inches, accompanied with 

 induration and tumefaction of the subjacent connective tissue. After 

 the tenth day, the areola begins to fade, and the vesicle at the same 

 time begins to dry in the centre; the lymph becomes opaque arid 

 gradually concretes, and by the fourteenth or fifteenth day, a hard 

 mahogany-coloured seal> is formed which contracts, dries, blackens, and 

 fall.- off between the twentieth and twenty-fifth days. A circular, 

 depressed, foveated, and sometimes radiated scar remains behind. 

 By >e]ectin,i,' ch:ir,-icteri>tie ve>icles on the calf or on the human 

 Millet, and by collecting the lymph at an early Maire on the fifth, 

 sixth, or seventh day, this artificial disease, commonly known ifl 



