GLANDERS. 



>id. <>f the track of the needle; on -.'lycerine-agar with milk a 

 whitish layer develops, which gradually chang, .., f n)m 



amber yellow to a reddish-brown. On blood >enim the growth U 

 transparent and yellowish ; on potato it is much more charact. i 

 After two or three days at the temperature of the 1,1, MM!, .-, tilm 

 develops in the vicinity of the inoculated area, which is honey-like, 

 transparent and yellow ; the transparency disappears, and i< 

 week the cultures have become reddish-brown. (Plate II., Fig. '. ) 



The disease has been communicated to man by accid> 

 inoculation with a hypodermic syringe which had been used 

 inoculating cultures. Horses, asses, cats, goats, field mice, and 



<$4t)' 



FIG. 185. SECTION OF A BRANCH OF THE PULMOXAKY AKTEKY .SHOWING 

 GLANDERS BACILLI PENETRATING THE WALL (HAMILTON). 



guinea-pigs, can all be infected with pure culture.-; ra .!> 

 and dogs are slightly susceptible; cattle, swine, and white mice 

 have an immunity. In the guinea-pig a swelling occurs at the seat 

 of inoculation, followed by the formation of a prominent tumour, 

 developing into an abscess. The skin becomes involved, and ..n 

 with indurated margin results. The lymphatic glands also become 

 implicated, and general, infection follows, extending frequently to 

 the testicles or ovaries, and death results after several weeks. 

 rabbits there is generally only a local abscess induced, which termi- 

 nates in a quickly-healing sore. Mice die in three or four days 

 from general infection; glanders nodules are found in the live,- and 



