USE OF ANIMALS 173 



leucocytes. The heart and voluntary muscle fibres usually 

 show degenerative changes. Occasionally there is fatty de- 

 generation of the liver and kidneys. The number of leuco- 

 cytes in the blood is increased. From the area surrounding 

 the point of inoculation, virulent bacilli may be obtained, but 

 in the internal organs they are only occasionally found, unless 

 an enormous number of bacilli have been injected. Paralysis, 

 commencing usually in the posterior extremities, and then 

 gradually extending to other portions of the body and caus- 

 ing death by paralysis of the heart or respiratory organs, is 

 also produced in many cases in which the inoculated animals 

 do not succumb to a too rapid intoxication." 



