264 MICROBIOLOGY 



spaces between the cells and fibers. In old lesions the bacteria 

 are more numerous than in the early stages of the disease. 



It was first thought to be a case of avian tuberculosis in 

 cattle. M'Fadyean 2 described this disease in England. It 

 has been found a number of times in this country. A descrip- 

 tion of its artificial cultivation has not appeared. Olaf Bang 3 

 found that cattle suffering with this disease gave a reaction to 

 tuberculin prepared from the avian variety of tubercle bac- 

 teria. 



Stockman 4 has described acid-fast bacteria similar to 

 those of Johne's disease, in the intestine of sheep. In scrapings 

 from the intestine, bacteria appeared in great numbers and in 

 dense clumps as in Johne's affection. They were also found in 

 the mesentery lymphatic glands. Sections of the glands failed 

 to show any tissue changes suggestive of the formation of 

 tubercles. 



LEPROSY-LIKE BACTERIA IN ANIMALS. 



Dean x investigated a disease of rats in England resemb- 

 ling leprosy in which he found enormous numbers of acid-fast 

 bacteria in the cells which, however, he could not cultivate. 

 This leprosy-like disease of rats was first described by Ste- 

 fansky 2 in 1903. He pointed out two distinct types, one in 

 which the skin and musculature were involved and the other 

 where the lesions were confined to the lymphatic glands. 



Wherry 3 found in a study of the leprosy disease of rats 

 that the organisms were taken up by flies that fed upon the 

 carcasses of the leper rats. He showed that flies thus infected 

 deposited the organisms with their feces. They did not mul- 



2 M'Fadyean. Jour, of Comp. Path, and Therap., Vol. XX (1907) 

 p. 48. 



8 Olaf Bang. Ninth International Vet. Congress, The Hague, 

 1909. 



4 Stockman. Jour, of Comp. Path, and Therap., Vol. XXIV 

 (1911) p. 66. 



'Dean. The Jour, of Hygiene, Vol. V (1905) p. 99. 



'Stefansky. Central bl. f. Bakt, Bd. XXXIII (1903) p. 481. 



'Wherry. Jour, of Inf. Dis., Vol. V (1908) p. 507. 



