GENUS BACTERIUM 281 



38 C. In the fermentation tube the closed bulb may become 

 cloudy and the open one remain clear. It does not multiply in 

 bouillon free from dextrose or lactose. It retains its virulence 

 after several generations. Its virulence is increased by passing 

 it through pigeons. It is rapidly attenuated at a temperature 

 of 45 C. 



Resistance. It is destroyed at a temperature of 55 C. 

 in a few minutes. There seems to be little data relative to its 

 resistance to disinfectants. Cultures that have been under 

 cultivation for several generations are promptly killed by the 

 ordinary disinfectants. 



Pathogenesis. In addition to swine, this organism is 

 pathogenic for rabbits, mice and pigeons. Death follows in 

 from three to seven days after an intravenous (rabbit and 

 pigeon) inoculation with a small (0.15 to 0.25 cc.) quantity of 

 a culture. Pigeons are especially susceptible. Other animals 

 seem to be immune. 



Vaccine. Pasteur and Thuillier prepared a vaccine from 

 attenuated cultures which gave very satisfactory results. Pigs 

 that recover from an attack possess considerable immunity. 

 Lorenz 9 and Emmerich 10 employed a blood serum for im- 

 munizing purposes. 



BACTERIUM MURISEPTICUM (FLUGGE) MIGULA. 



Synonyms. Bacillus murisepticus Koch l ; Bacillus mu- 

 rinus Schroter. 2 



Place in nature. The Bacterium murisepticum is the 

 cause of a septicemia in mice. It was discovered by Koch in 

 1878. It has been found and described by Smith 3 and Moore * 



9 Lorenz. Deut. tierartz. Wochensch., 1893, pp. 41 and 85. 



10 Emmerich. Ibid, 1893, p. 127. 



1 Koch. loc. cit. 



2 Schroter. Kryptogamenflora von Schlesien, Bd. Ill (1886) p. 

 162. 



3 Smith. Second Annual Report B. A. I., U. S. Dept. Agric., 1885, 

 p. 196. 



4 Moore. Jour. Comp. Med. and Vet. Archives, Vol. XIII (1892) 

 p. 333. 



