416 MICROBIOLOGY 



in many other spirochaetae by being extremely steep, or, in 

 other words, by forming acute, rather than obtuse, angles. 

 The ends of the microorganism are delicately tapering and 

 come to a point. In his first investigations, Schaudinn was 

 unable to discover flagella and believed that he saw a marginal 

 undulating membrane similar to that noticed in the trypano- 

 somes. Later observations by this observer, as well as by 

 others, revealed a delicate flagellum at each end, but left the 

 existence of an undulating membrane in doubt. Uncertain, in 

 his later investigations, whether the microorganisms described 

 by him could scientifically be classified with the spirochaetae 

 proper, Schaudinn suggested the name of "Treponema 

 pallida. ' ' 



SPIROCHAETA DUTTONI. 



This spirochaete was found by Button in 1905 to be the 

 cause of African tick fever. It resembles very closely Sp. 

 Obermeieri. 



Several other spirochaeta have been found in the human 

 body but those mentioned are the most important etiologically.* 



NEGRI BODIES. 



Synonyms. Bodies associated with the brain cells in 

 cases of rabies. 



Place in nature. Negri bodies are minute structures that 

 were discovered by Negri of the University of Parva in 1903 

 in the brain cells of cases of rabies or hydrophobia. The cause 

 of this disease has been the object of many researches but it 

 defied the efforts of investigators until Negri made the dis- 

 covery of bodies which he believed stood in a causal relation 

 to the disease. They have been thought by some workers, how- 

 ever, to be a specific degeneration associated with the cause. 

 They can be found in the brain of practically every animal 



* The student is referred to the papers of Uhlenhuth and Haen- 

 del, Fritz Schaudinn, and Prowazek for details relative to the 

 Spirochaetes of recurrent fever, and those closely allied to Trepo- 

 nema pallida. (Arbeiten a. d. Kais. Gesundheitsamte, Bd. XXVI 

 (107). 



