FILTERABLE VIRUSES 433 



from pustules from cases of sheep-pox when diluted with water 

 and passed through a Berkefeld filter retained its virulence. 



Cow-pox. The virus of cow-pox was shown by Ren> 

 linger (Bull, de 1'Inst. Pasteur) to pass through the Chamber- 

 land filter. His results have been confirmed by several other 

 workers. Likewise the cause of the equine pernicious anemia 

 is looked upon by some as being due to a filterable virus. 



According to Carre, canine distemper should be added 

 to the list of diseases caused by a virus that will pass through 

 the Berkefeld filter. 



Ellermann and Bang 22 have recently described a leuco- 

 cythaemic disease of fowls in Denmark in which they consider 

 the cause to be an ultravisible virus. 



Epizootic cerebro-spinal meningitis. Joest and Degen 2S 

 have described in the nerve cells of horses suffering from epi- 

 zootic cerebro-spinal meningitis intranuclear bodies resembling 

 somewhat the Negri bodies found in rabies. They appeared in 

 the nucleus of the ganglion cells and never in other cells or 

 lying between cells and fibres. They vary in size from fine 

 points to about the size of the red blood corpuscles. They 

 take stains quite similarly to the Negri bodies. They also stain 

 after the Gram-Weigert method, using eosin as a counter-stain. 

 They also stain after Giemsa's method in which the bodies 

 have a pale blue appearance while the nucleolus is stained a 

 deep dark blue. Safrenin stains them a pale yellowish brown 

 while the nucleus is an intense yellowish brown. 



Their observations were based on 27 cases of the disease 

 in 24 of which the bodies were found. The findings of Joest 

 and Degen suggest that these bodies may be of value in diag- 

 nosing cerebro-spinal meningitis from other diseases that 

 might be confused with it. 



^Ellermann and Bang. Centralbl. f. Bakt., Bd. XLVI (1908) 

 p. 595. 



2a Joest and Degen. Zeit. f. Infekt. * * * der Haustiere, Bd. VI 

 (1909) p. 348. 



