16 



Itagaki 



Does Corpus luteum act through the Uterine Nerves or 

 directly on the muscular tissue ? 



I have further made a number of experiments with the object of 

 ascertainino- on what part of the neuro-muscular mechanism of the 

 uterus an extract of corpus luteum acts, i.e. whether it produces its 

 effect by stimulating nerve-endings or whether it is a direct action upon 

 the muscular tissue. These experiments consisted in the successive 

 application of adrenalin solution and corpus luteum extract to the same 

 uterus (rabbit), and in the successive application of adrenalin (Parke, 

 Davis & Co.) and corpus luteum extract to the uterus of different kinds 

 of animals. The results are given in Tables Y., VI., YII., and VIII. 



Table V. — Rabbit. 



No. 



2 

 3 



Date. 



13.2.15 



14.5.15 

 25.6.15 



Table VI.— Rat. 



Dose. 



1 : 10,000 



Adrenalin. 



Decrease of tone and in- 

 hibition of rhythmic 

 movements. 



Corpus luteum. 



Dose. 



5% 



2% 



Increase of tone 

 and rate of 

 rhythm. 



Table VIL— Cat. 



I 



