28 Itagaki 



hilum shows a diminution in the rhythm of contraction, whicli may 

 be accompanied by a marked relaxation of tone. Out of forty experiments, 

 thirty-one showed diminution or inhibition of rhythmic movements, with 



Fig. 1. — Effect on cornu of rat-uterus of addition of extract of hilum ovarii to the Locke's solu- 

 tion in which the tissue was immersed. Notice the immediate cessation of the rhythmic 

 movements and marked diminution of tone of the muscle. At L the extract was replaced 

 by simple Locke's solution. 



The time in this and in all the other experiments with the isolated tissue is marked 

 in minutes. 



Fig. 2. — Efiect of extract of hilum ovarii (10 per cent.) upon surviving uterus of rat. The extract 

 was applied at the first arrow (left) and re{)laced by simple Locke's solution at the second. 

 Notice that the rhythmic movements recommence even during the continuance of the extract. 



or without relaxation of tone; live showed inhibition of rhythmic 

 movements followed after a time by a recurrence of contractions ; in three 

 no change was observed ; in one, as above mentioned, there was increase of 

 tone from the first. 



