Action of Extnicta of Ovary on Plain Muscle 



29 



Action on Uterus of Ilabhit. 



I have made five experiments on the uterus of the rabbit, the strength 

 of the extract varying from 5 per cent, to 10 per cf»nt. In four of these 



Fig. 3. — Etrect of extract of. hilum ovarii on uterus of rabbit. Notice the increase 

 of tone. The extract was added at the first arrow and replaced by simple Locke 

 at the second. 



a distinct increase of tone was produced by extract of hilum (fig. 3) ; in 

 the fifth no distinct change. 



Action on Uterus of Cat. 



I have made two experiments on the excised cat's uterus, the strength 

 of the extract being 5 per cent, and 10 per cent. In both cases great 

 increase of tone was produced by it. In addition to these two experiments, 

 four others were made upon the uterus in situ (one of the cornua being 

 connected by a thread with a muscle lever), an injection of 5 c.c. of a 

 5 per cent, extract being made slowly into the jugular vein. In two of 

 these experiments the uterine tone was increased. In the other two 

 relaxation was produced, but in one of these the relaxation was preceded 

 by an initial contraction (fig. 4). Two experiments were made with 

 excised uteri of kittens. Here also an increase of tone was produced, 

 although not nearly as well marked as with the uterus of the cat. 



Action on Uterus of Guinea-pig. 



A 5 per cent, to 10 per cent, extract was again used. In four 

 experiments upon the uterus of the guinea-pig, all showed an increase of 



