32 Itaofaki 



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1 



Effects on Blood-pressure. 



Lambert (2) states, with regard to extract of ovary containing no 

 corpus luteuni, that this has no toxic and no physiological activity. 

 Below (3), on the other hand, found that extract of ovary minus corpus 

 luteum ("Proovar" as he terms it) causes a rise in blood-pressure and 

 accelerates the pulse-rate. Biedl (4), however, could not confirm this with 



Fig. 6. — Effect of extract of liilum on a longitudiual strip of small intestiiifi of 

 rabbit. Notice the marked decrease of tone and cessation of rhythmic move- 

 ments. At the second arrow the extract was replaced by Locke. 



an extract furnished to him by Poehl. I have performed in all seven 

 experiments upon cats ana3sthetised with chloroform, an injection of 

 5-10 c.c. of a 5 per cent, to 10 per cent, extract being made into the 

 jugular vein. All show a distinct fall of blood-pressure (fig. 4), although 

 the rate of the pulse is not diminished. The fall of blood-pressure was 

 also produced after atropin had been previously injected. It is therefore 

 a vasodilator effect. 



Extract of Liquor Folliculi. 



Extract of liquor folliculi was made in the following way. To a 

 certain number of cubic centimetres of the filtered liquor obtained from 

 large Graafian follicles Locke solution was added to make the fluid up to 

 100 c.c. This was then boiled and filtered, and the filtrate made up to the 

 original volume by the addition of distilled water. 



Action on Uterus of Rat. 



I have made sixteen experiments upon the rat's uterus, with extracts 

 of from 2 per cent, to 12 per cent, of liquor folliculi. In most cases this 

 extract produced an increase of tone in the uterus (fig. 7) ; when the 

 rhythmic contractions were in abeyance, it had the eflect of inducing 

 these to recommence. In one case, however, relaxation of the uterus was 

 produced instead of contraction. The increase of tone was also obtained 

 from a uterus in the pregnant condition. In two out of the sixteen cases 

 no change was observed. 



