Action of Kxtracts of Ovary on Plain Muscle 37 



Action on thf Intt-stine. 



I have made four experiments with the rabbit's intestine, using the 

 whole tube, and extracts of from o per cent, to 10 per cent. In every ca.se 

 an increase of tone was pro<luced (ti<;. 1 1 ). 



Action on Blood-pressure. 



Gizelt (9) noticed a fall of blood-pressure to be produced by injecting 

 ovarian extract into the dog. Schickel e (10) found that extract of cow's 

 ovary made with cold physiological salt solution produced only a slight and 

 evanescent fall of blooil-pressure ; sometimes there was a rise instead of a 

 fall. On the other hand, the expressed juice of the ovary obtained by the 

 use of high pressure caused a fall of blood-pre.ssure which continued for 

 several minutes, even when a minute do.se was given. Schickele was only 

 able to obtain this result in the dog and rabbit, and Biedl (11) considers 

 the efiect to be non-specific. In my own experiments, an intravenous 

 injection of 5 c.c. of a 5 per cent, to 10 per cent, extract always produced 

 a marked fall of blood-pressure in the cat (fig. 12). 



Summary. 



1. Extract of hilum ovarii has the opposite effect to extract of corpus 

 luteum upon the movements of the rat's uterus, for it causes inhibition 

 instead of contraction. The uterus of other animals is atiected diti'erently, 

 for in the rabbit, cat, and guinea-pig an extract of the hilum usually has 

 the result of producing an increase of tone. 



2. Liquor folliculi produces an increase of tone of the uterine mu.scle in 

 the rat, rabbit, and cat, or at any rate an increase in height of the rhythmic 

 contractions. 



3. When applied to the whole thickness of the inte.stinal tube, all the 

 extracts tested — hilum, liquor folliculi, and whole ovary — determine an 

 increase of tone, whereas a strip of the longitudinal coat of the rabbit's 

 intestine is .sent into relaxation by extracts of hilum. 



4. A fall of blood-pressure is produced by intravenous injection of all 

 the extracts employed — hilum, liquor folliculi, and whole ovary. 



BlBLIOGRAl^HY. 



(1) Itaqaki, this Journal, preceding paper. 



(2) Lambert, Compt. vend. soc. biol., 1907, Ixii. 18. 



(3) Below, Monatsschr. f. Geb. u. Gyn., 1910, xxxvi. Quoted from Biedl, 

 Innere Sekretion, 1916, ii. 290. 



