Action of ceitiiin (Hand Kxtracts and I)rui;s upon I'terus of Knt 45 



stiencrtli of 1 : 20,000 tin- individual contractions are increased in hei<;ht 

 witliout the tjeneral tone beini; arteeted. With a strength of 1 : 10,000 

 there is a slight diminution in the lieiglit of the contractions ; but even with 

 a strong sohition, such as 1 : 1000, I have failed to get complete inhibition. 



r.AKlIM ('llLoUll)E. 



Kelirer (10) describes the production of strong contraction in the 

 uterus of the cat l)y solutions of this salt. 



The streiiirth of the solutions which I have used for the excised rat- 

 uterus has been from 1 : lOO.OOO to 1:1000. Even with a .strength of 



Fig 4 — Ktlect of barium chloride (1 in 20,000) on the excised uterus of rat. The drug was added 

 to the Locke's solution at the fir.st mark and removed at the second. Notice not only an 

 increase of tone of the muscular tissue, but also an increase of rate of the rhythmic contractions. 



1 : 100,000 an increase of tone is obtained ; with stronger .solutions, the 

 uterus passes into a condition of pronounced contraction (fig. 4). 



Summary. 

 The results of these experiments upon the rat-uterus may be briefly 



stated thus : — 



1. Extract of posterior lobe of pituitary always produces an increase 



ot" tone. 



2. Solutions of adrenalin inhibit the rhythmic contractions (with or 



without diminution of tone). 



3. Extract of thyroid occasionally produces an increase of tone, but 



generally has no effect. 



