FA'PERIMEXTAL OPERATIONS ON THE PITITITARV.' 

 By \V. Blair Bell. ( With Hfty-seven illustrations in the text.) 



I 



{Received for publication 22nd Se2>tember 1916.) 



CONTENTS. 



Introduction ...... 



Opkrative Tkchmque ..... 



ThK EfFKCT.S ok THK Ol'ERATIOXS : — 



A. Control experiiuent-- ..... 



B. Total extir2)ation of the pituitary 



C. Partial extirpation of the pituitary 



(1) Anterior lolie removal.^ .... 



(a) Total removal of tlie pars aulerioi 



(b) Partial removal of the pur.s anterior 



(2) Posterior lobe removals .... 



(a) Total removal of the pars posterior 



(b) Partial ivnioval of the par.s posterior 



(3) Combined partial anterior and posterior lobe removals 



D. Clamping and separation of the stalk 



E. Imitation tumours in the neighbourhood of the pituitary 

 DiscL's.sioN 01'" Results ..... 

 Conclusions ....... 



fAOR 



77 

 78 



88 

 90 

 93 

 93 

 93 



9f; 



103 

 103 

 104 

 lOS 

 108 

 116 

 120 

 125 



Introduction. 



The experimental work described in this communication was curtailed 

 by the outbreak of war ; and, for the same reason, the examination of the 

 material obtained and the arrangement of it for publication have been 

 greatly delayed and hampered. 



These investigations were carried out in order that the following points 

 micrht be studied : 



(1) The general effects produced by pituitary lesions; (2) the effects of 

 these lesions on the genitalia; (3) the effects produced by the pituitary 

 lesions on the other organs of internal secretion. 



It was anticipated that evidence would be obtained in confirmation or 

 refutation of the recent work on the same lines; while the possible acquisi- 

 tion of fresh information was kept in view. 



Experimental operations on the pituitary, so frequently attempted since 

 Victor Horsley (1886 (14)) fir.st entered the field, have probably not been 

 satisfactorily accomplished by as many as half-a-dozen operators. 



' A Hunterian lecture was delivered by the author on these experiments at the Royal 

 College of Surgeons, England, on 11th February 1916. 



