90 



Blair Bell 



were lesions found in tlie brain which could have accounted for the 

 convulsive seizures. 



In Table I. are given the details of these control experiments. One 

 of the bitches (No. 9) before and 152 days after operation is shown in 



Table I. — Control Experiments. 



y 



' This animal and dog No. 2 were kept side by side in the animal house. Both died with 

 convulsions within a few hours of one another many months after operation. Strychnine poisoning 

 was suspected, but the examination of the stomach of this dog gave a negative result. 



figs. 14a and l-lB. It will be observed that there is no change in the 

 animal except some slight increase in size corresponding with the 

 increase in aee. 



Total Extirpation of the Pituitary. 



This operation (figs. 15 and 16) was effectually carried out on six 

 animals. In all cases a few cells of the reticulated portion of the pars 

 intermedia must necessarily be left at the base of the brain, otherwise 

 the third ventricle would be opened and part of the base of the brain 

 removed. 



The first animal died shoi'tly after the completion of the operation ; 

 so soon that it is possible that death wvis due to an overdose of ether 

 which was used too freely during the operation. Of the other five all 

 died within a short time ; that is to say, within periods ranging between 

 22 and 36 hours. In all these five cases the animals recovered from the 

 anaesthetic, and were able to take nourishment freely. Before long, how- 

 ever, they became somnolent, and although it was sometimes possible to 

 rouse them from this condition, and to get them to stand and take food, 

 they quickly became somnolent again as soon as they were left alone. 

 After a few hours the respirations became very slow and coma set in ; 

 finally death supervened. The details of these operations are shown in 

 Table II. 



