98 



Blair Bell 



in weight. Unfortunately only two bitches were weighed before as well 

 as after operation, and of these No. 3 — shown before, and 210 days after 

 operation in figs. 22a and 22b — lost weight subsequent!}^ to operation ; the 

 other, No. 19, increased in weight in accordance with its normal increase in 

 growth. Some of the animals when recovering from the operation showed 

 the peculiar condition of somnolence already described in connexion with 

 total removal of the pituitary. As recovery occurred this state gradually 

 passed off. 



Changes in the other endocrine organs were not found except, possibly, 

 in the case of the thyroid from bitch No. 24. In this animal the thyroid 





■-.'■'A .m.iJ h-&,J-^ f T 



Fig. 23. — Section of tlie thyroid of dog 24, 40 days after jjaitial removal 

 of tlie pars anterior. (Photoniicrograph x 40.) 



was observed macroscopically to be considerably enlarged, but on histo- 

 logical examination the organ was found to be normal (tig. 2.S). 



The variability in the results obtained would not be difficult to under- 

 stand if it were only in the case of the removal of small portions of the 

 pars anterior that no symptoms were produced, while excision of large 

 portions produced changes in the general condition of the animal, in the 

 genitalia and in the other endocrine organs. But these were not the results 

 that were obtained ; and it is difficult to understand why the removal of 

 large portions from one animal — No. 19 — should give rise to no ill effects, 

 while the removal of smaller pieces, as in some of the other animals, should 

 cause definite changes in the genitalia. 



In three out of the five cases in which portions of the pars anterior 

 were removed the uterus (figs. 24a and 24b) and ovaries (figs. 25a and 2.5b) 

 were definitely atrophied. In these circumstances one finds that there is 



