120 Blair Bell 



specific condition. It is typical in the dog of general emaciation and 

 weakness, due to any cause. This animal had some slight suppuration in 

 the abdominal wound, and also contracted mange; consequently it is 

 difficult to know how much of the emaciation to ascribe to pituitary 

 irritation. 



The other animal (Xo. 22) showed no symptom whatsoever. There 



Fig. 46, — Dog 20, 98 days after operation, showing the emaciMtion and attitude 

 of weakness caused bj' glycosuria due to the pressure on the jiituitar}- of 

 an imitation tumour. (Photograph.) 



was a considerable increase in weight, which was probably due to rapid 

 growth and not to obesity. 



Discussion of Results. 



It will now be of interest to see how far the foregoing experiments 

 confirm or contradict the work of others. En this connexion it will be 

 sufficient to consider the pioneer work of Paulesco (1908 (16)), and the 

 subsequent experiments of Gushing and his colleagues (1909 (17)) and 

 (1910 (6)) and of Biedl and his associates (1910 (4)). 



The work of Aschner (1910 (1)) is less reliable, for although this 

 investigator was able to produce certain of the abnormal phenomena that 

 had been previously recognised by others, his methods, which have been 

 justl}- criticised by Biedl, were not exact, since he used the oral route. 

 Ascoli and Legnani (1912 (2)) also, so far as I can gather, do not appear 

 to have clearly recognised that different lesions produce different results. 



Paulesco's work, on the other hand, is of the highest merit, for by 

 introducing the bitemporal route he at once placed the experimental 

 possibilities on a sound basis. The results which he obtained may be 

 summarised as follows : — 



