STUDIES ON TIIK ENDOCRINE GLANDS :— PAPER I.: THE 

 RELATIONS P.ETWEEN THE PANCREAS AND THYROID 

 AND PARATHYROID GLANDS. By Masaharu Kojima, 

 Fleet Surt^eon, Iinperial Japanese Navy.^ (From the Pliysioloi^y 

 Department of Edinlnirgh University.) (\Vith twenty-nine figures 

 in the text and two coloured plates.) 



(Received for publication 1st December 1910.) 



CONTENTS. 



Method.s of Investigation 



Preparation of extracts ... 



Diet and treatment .... 



Operative procedures .... 



Microscopic methods 

 Effects upon the R.\t of Removal of Thyroid and Parathyroid, and of 

 Administration of Thyroid and Parathyroid 



Microscopic appearances of pancreas of rat — 



(a) in the normal animal ..... 



(b) after jiarathyroidectomy 



(c) after tliyroidectomy ..... 

 Effects of tliyioid feeding — 



(a) in tlie unoperated animal .... 



(b) after parathyroidectomy .... 



(c) after thyroidectomy ..... 

 Effects of jiarathyroid feeding — 



(a) in the unoperated animal .... 



(b) after parathyroidectomy .... 



(c) after thyroidectomy . . . . 



Thyroid feeding in different .sexe.s .... 



Thyroid feeding during varying periods 



Thyroid feeding with intermi.ssion, and also with increasing doses 



Effects of thyroid feeding on weight of pancreas 



Effects on the amount and quality of the urine . 



Small dose.'^ of thyroid ...... 



Prolonged feeding with thyroid ..... 



Feeding with water-e.xtract of thyroid and with its residue 



Feeding with alcohol- and ether-extracts of thyroid and with the residue after 



such extraction .... 



Subcutaneous administration of thyroid extract 



HACK 



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1 The author desires to record his acknowledgments to Professor Schaf er for assistance 

 and advice in carrying out these investigations. The expenses have been defrayed by 

 grants from the Earl of Moray Fund for the Endowment of Re-earcli in the University of 

 Edinburgh, and from the Carnegie Trust for the Universities of Scotland. A preliminary 

 account of some of the results was comniuiiicaLed to the Royal Society of Edinburgh on 

 July 3, 1916, and is published in the Proceedings (I). 



VOL. XI., NOS. 3 AND 4. — 1917. 17 



