256 



Kojima 



Thyroid Feeding of Castrated Rats ...... 



Does castration alone affect the structure of llie jiaucreas ? . 



Does previous castration affect the results of thyroid feeding on the pancreas? 

 Does the Administration of Combinations op Iodine with Protein affect 

 THE Pancreas in the same manner as Administration of Thyroid 

 Substance ? . 

 What is the Effect upon the Pancreas of administering Iodides and 

 other Salts ? . 



Sodium iodide ...... 



Potassium iodide ...... 



Sodium bromide, sodium chloride, and sodium fluuride 



Sodium carbonate, sodium phosphate, and sodium sulphate 

 Effects of administering certain Hormonic Substances 



Pilocarpine 



Adrenalin 



Pituitary body 



(a) Anterior lobe 



(b) Posterior lobe 

 Experiments on Thyroid Feeding 



Mice 



Cats and dogs 

 Rabbits and guinea-pigs . 

 Birds 

 General Summary . 



of Animals other than Rats 



PAGR 



29U 

 291 

 291 



293 



294 

 294 

 298 

 300 

 300 

 302 

 302 

 302 

 303 

 303 

 303 

 306 

 306 

 307 

 310 

 311 

 314 



Methods of Investigation. 



These investigations had for their original object the determination of 

 the effects of extracts of certain of the endocrine glands upon other organs, 

 but in this paper the observations deal for the most part with the relations 

 between the thyroid and parathja-oids and the pancreas, the experiments 

 having been chiefly designed to observe the effects of thyroidectomy, of 

 parathyroidectomy, and of feeding with thyroid and parathyroid upon 

 the pancreas. 



Preparation of Extracts. 



The glands and gland-extracts which have been employed for feeding 

 are the thyroid of the ox and sheep, and the parathyroid of the ox. In 

 some of the thyroid-feeding experiments fresh glands were employed ; in 

 others dried material was used. This was prepared in the following way : — 

 Fresh glands from the ox, obtained direct from the slaughter-house, were 

 freed from the surrounding tissues. They were then minced, and the 

 material placed in a thin layer upon a glass plate, on which it was dried in 

 an incubator at 37° C. The dried material was ground up with a mill, and 

 was then kept in an exsiccator. Extracts of this or portions of the gland 

 substance itself were added in a small but definite amount to the food of 

 the animal : this food was of fixed quality throughout. For parathyroid 

 feeding, glands of the ox which had been collected and preserved for a 

 time in chloroform were employed, the glands being minced and dried in 

 the manner above described. The animals used for feeding experiments 

 were for the most part white rats, generally adult, i.e. sexually mature, 



