268 



Kojima 



Fig. 9. — Section from the same pancreas as that shown in fig. 8, but stained 

 with Mallory iu^stead of ha>matoxylin. Micropliott'grajih ; magnified 

 100 diameters. 



This photograjjh is to be compared with that shown in fig. 4. Notice 

 the considerable diminution in the amount of zymogen, which is still, 

 however, accumulated in greatest amount in the alveoli which are 

 adjacent to the islet. 



(b) In Parathyroidectomised Animal. 



No. 2 rat of B group. Thyroid-fed. Weight 205 grm. Killed forty- 

 two days after parathyroidectomy. 



Both lungs are slightly congested, especially at the base. The liver is 

 also congested. The large intestine is normal in appearance, but its contents 

 are soft. The thyroid glands are paler than normal. 



Pancreas. — As seen under a low power, the alveoli appear on the 

 whole smaller than in the controls. Both in size and shape the 

 alveolar cells vary considerably (as in the unoperated thyroid-fed 

 animal). Some cells contain vacuoles. Many of the nuclei of the 

 alveolar cells are large, measuring from 7'5/(x to 10^ ; they are stained 

 deeply with ha3matoxylin,and show a coarse granulation of chromatin, 

 with sometimes an enlarged nucleolus. Small nuclei (3*7/x) belonging 

 to small cells are also seen in great number. These are closely set, 

 as if the}^ had just completed division. Many of the alveolar cells 

 exhibit mitoses, but these do not appear so numerously as in the 

 animal just described. Zymogen granules are more scanty than 

 normal. The nucleoli, when visible, are, in Mallory preparations, 

 sometimes blue, sometimes red. Paranuclei are occasionally seen in 

 the cells which exhibit mitosis. As in the case just described, zymogen 

 granules are scarce in these dividing cells. Zymogen granules are 



