270 



Kojima 



Oil account of the mortality amongst the group of thyroidectomised 

 rats fed with thyroid, and with the view of confirming the results 

 obtained under these circumstances, another full-grown male rat (No. 120) 

 was subjected to thyroidectomy on September 16, 1916. From October 

 4 to 9 there was added to its normal diet 1 grm. of dry ox- thyroid per diem. 

 From the third day of this diet the animal sufl:ered from slight diarrhoea, 

 and appeared inactive, with a distinct decrease of appetite. The skin also 

 had an unhealthy appearance. Before the thyroid feeding the weight of 



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Fig. 11. — Part of a section of the same pancreas as that sliowii in fig. 10, magnified 

 500 diameters. Hferaatoxylin ])rei>aration. 



Considerable variation in size of the alveolar cells and of their nuclei is apparent. 

 The large nuclei contain abundance of coarse chromatin granules which are deeply 

 stained with hpeniatoxylin. Several cells show mitoses. There is a general diminu- 

 tion in the amount of zymogen (clear zone). 



the animal was 265 grm. After six days' thyroid feeding it was 250 grm. 

 It w^as then killed. 



Post-mortem. — The contents of the large intestine are soft. The 

 weio-ht of the pancreas is 1'6 grm.; the ratio of the pancreas to body- 

 weight is 1:156'2. (This will be afterwards referred to.) 



Pancreas. — The alveoli generally are small. Their cells vary in 

 size, and also their nuclei ; the latter measure between 3'7/i and 10^, 

 but most are from hfx to 6-2/x. Some of the larger nuclei stain par- 

 ticularly deeply wdth hasmatoxylin. These have scattered chromatin 

 granules. Others contain a large nucleolus, staining red with Mallory, 

 with a tendenc}^ for the chromatin granules to be arranged near the 

 periphery of the nucleus. A considerable number of cells exhibit 

 mitotic figures. These cells are generally of large size. Paranuclei 

 which stain red with Mallory are seen in them. Zymogen granules 



