Studies on the Endocrine Glands 



275 



From May 1!> to May '2.3 the parathynjid was left out, and the diet 

 consisted of ground rusks and water alone. Between ^lay 26 and June 5 

 the animals received an addition of 3 crrm. of fresh sheep's thyroid per 

 rat per diem to the ordinary diet.^ During the period of parathyroid feed- 

 ing none of the animals showed any special symptom, but from the third 

 day of the thyroid feeding they had diarrluea and their appetite dimin- 

 ished. There was also an ettect produced upon the skin, the hair falling 

 out much more than before. On June G all the animals were killed and 

 their organs placed in 10 per cent, formol solution. 



Fig. 12. — Section of the pancreas of a rat (female) fed with the addition to tlie ordinary 

 diet of 4 grm. of fresh sheep-thyroid per diem during four days. The animal was 

 killed after one day's intermission of the thyroid. Microphotograph ; magnified 

 150 diameters. Mallory's stain. 



Notice the extensive vacuolation of many of thu alveolar cells. Two islets 

 are included in the section. 



Two of the animals exhibited marked congestion of both the small and 

 large intestines, the contents of which were watery. 



Pancreas. — The alveoli as seen in sections are distinctly smaller 

 than normal. The alveolar cells are also generally smaller, but 

 vary in size. Their nuclei measure from 3"7/z to 11 '2^, but most 

 of them are between 5/x and 7"5;ot. There are many small alveolar 

 cells. These have small nuclei staining deeply with hsematoxylin 

 and giving the appearance of having undergone proliferation. 

 Their nucleoli are enlarged and their chromatin granules coarse ; 

 zymogen granules are but few in number in these small cells. 



1 This is a little less than 1 grm. of dry thyroid, which is equivalent to 3 -5 gnu. fresh 

 thyroid. 



