284 * Kojinia 



Table IX. 



Weight of Pancreas and its Proportion to Body-Weight in Nine 



Normal Adult Male Rats. 



Effects of Smaller Doses of Thyroid. 



To determine whether smaller doses of thyroid than those we were 

 accustomed to use would produce the effects described, the amount of 



Fig. 15. — Pancreas of rat (male) which had been fed with an addition of 0"5 grra. of 

 dry ox-thyroid per diem to the ordinarj' diet during seven days, i.e. half the 

 quantity which had been previously used. Microphotograph ; magnified 450 

 diameters. Hfematoxylin preparation. 



Notice again the variation in size of the alveoli as well as of their cells : also 

 the occurrence of very large nuclei which contain abundance of coarse chromatin 

 granules staining deeply with hsematoxylin. Several of the cells exhibit mitosis. 



thyroid in the food was reduced to one-half, viz. to 0"5 grm. of dry ox- 

 thyroid per rat per diem administered with the rusk paste. Two full- 

 grown male rats (Nos. 25 and 26) were put on this diet from July 19 

 until July 25. Neither of these animals suffered from diarrhoea, but 

 their appetite and weight decreased from the fifth day of the feeding 

 onwards. The weights were respectively 180 grm. and 185 grm. at the 

 beginning of the feeding, and 175 grm. and 170 grm. at the end. The iodine 



