288 Kojima 



nuclei (d/x) (especially in Nos. 33 and 42). In preparations from all 

 these animals mitotic figures are seen here and there in the sections 

 of pancreas (fig. 16). Zymogen granules are on the whole scanty, 

 but there are individual difterences. Some of the alveolar cells have 

 vacuoles of medium size. 



In the animals belonging to groups C and D (Nos. 35, 36, 37, 38, 

 and 43, 44, 45, 46) the alveoli have much the same appearance as 

 in the others, but the outer zone is somewhat broader in proportion 



f, 







•I 



1 



1 



Fig. 16. — Section from pancreas of rat (male) fed with an addition to its ordinary 

 food of water extract (boiled) of 4 grm. fresh sheep-thyroid per diem during five 

 days. Microphotograph; magnified 450 diameters. Hsematoxylin preparation. 

 Notice again the variations in size of the alveolar cells and the remarkable 

 enlargement of their nuclei, which contain abundance of coarse chromatin 

 granules staining deeply with htematoxylin. In some of the cells vacuoles can 

 be made out. One cell m the field shows mitosis. The amount of zymogen is 

 considerably diminished as compared with the normal. There is no apparent 

 change in the islet-cells, the nuclei of which are not enlarged and are of nearly 

 equal size. 



to the inner, and there are many more small cells. The diameter 

 of the nucleus varies between 3*7/x and 7'5^i. A few are as large 

 as 9/A or 10/x. The nuclei are stained deeply by hsematoxylin ; they 

 contain abundance of coarse chromatin granules. The nucleoli are 

 somewhat enlarged, and are for the most part stained red by Mallory. 

 Mitoses are here and there present. The amount of zymogen varies, 

 being plentiful in some parts and scanty in others ; the diminution 

 is especialh' marked in the smaller cells. Vacuolation is visible in 

 many of the alveolar cells, and to some extent in the cells of 

 the islets. 



Summary, — The mitotic and other changes which have been already 

 described in the pancreas from administration of fresh and dry thjToid are 



