Studit's on the Endocrine CJ lands 



291 



Table XIII.— Effects of Castration ox Weight of Rats. 



' Killed on this date. 



Does Castration alone affect the Pancreas? 



Of the castrated rats two (Nos. 112 and 113) were killed thirty days 

 after the operation, and the two others (Nos. 110 and 111) forty-nine and 

 hfty-seven days respectively. 



Post-mortem the only obvious appearance was the increase of fat 

 which has just been mentioned. 



Pancreas. — On microscopic examination of the pancreas the 

 alveolar cells appear of nearly e(iual size throut,diout, but rather 

 smaller than in the normal gland. Their nuclei vary between 37ya 

 and Oyu. They have tine chromatin granules, and the nucleoli stain 

 red with Mallory. Some of the cells show a few small vacuoles in 

 their cytoplasm. There is no evidence of mitosis. Zymogen granules 

 are in most parts fairly plentiful. 



Does Previous Castration affect the Results of 

 Thyroid Feeding on the Pancreas? 



Another lot of four castrated male rats were now taken for the 

 experiment of thyroid feeding. These were operated upon on May 25, 

 and were separated into two groups, A and A' ; four other entire male 

 rats of equal size being also taken and separated at the same time into 

 two groups, B and B'. To A and B, 3 grm. of fresh sheep-thyroid 

 per rat per diem was administered along with the rusk diet, while to 

 A' and B' an equal amount of fresh lean meat (mutton) was added 

 instead of thyroid. 



All the castrated animals (A and A') were inactive during the tirst 

 week, apparently as the result of the operation. But even those with 

 thyroid feeding sutiered very little from diarrhrea, and the appetite was 

 fairly good. After the first week the thyroid-fed animals remained com- 

 paratively inactive in spite of the fact that the wound had completely 



