Studies on tlie Endocrine Glands 



297 



days with the usual paste of j^jround rusks, to which 0*05 grni. of sodium 

 iodide was added.^ This experiment was later repeated on three other rats 

 (Nos. 69, 70, 71), but with ditlerent doses. Hat No. G9, which received 

 01 grm., sufTcrt'd from diarrhd-a from the second day onwards, with 

 diminished appetite. Its weight at the end of the time was, however, 

 hardly diminished. Rat No. 70, to which 0-2 grm. of sodium iodide was 

 administered, showed a slight diminution of appetite and slight diarrh<>*a ; 

 but again there was no change in the weight. Rat No. 71, which received 

 0'3 orrm. of sodium iodide, showed occasional diarrhci-a and suffered con- 

 siderable loss of weight, viz. from 170 grm. at the beginning to 150 grm. 

 at the end of the experiment. In all cases there was strong positive evi- 

 dence of iodine in the urine : it was first found in urine which had been 

 collected nine hours after the commencement of the administration, but may 

 well have been present .sooner. 



Post-mortem nothing noticeable. 



Pancreas. — The pancreas of rat No. 68 was not examined. In 

 the others the appearances are nearly normal, zymogen granules 

 being plentiful in all the alveoli (fig. 19). There is no evidence of 

 mitosis, and very little sign of vacuolation. 



It follows from this that when sodium iodide is adminis- 

 tered to rats deprived of the thyroid, the effects are not the 

 same as when the thyroid is present. 



Table XV.— Effects of administering Sodium Iodide to Rats. 



1 One of these animals (No. 68) died on the second day, probably from some accidental 

 cause. It showed on post-mortem e.xamination a considerable amount of general congestion 

 of the intestines. 



