302 Koji 



ima 



granules are abundant in all the alveoli. In neither animal could 

 any change be detected in the cells of the islets. 



Summary of the Effects of Salts. — Of the various salts examined, 

 sodium iodide appears to be that which produces the greatest effect upon 

 the pancreas, although a certain amount of effect is produced by other 

 sodium salts. The most interesting change is the production of mitosis 

 in the alveolar cells. It is noteworthy that this is not obtained when 

 sodium iodide is administered to rats which have been previously thyroid- 

 ectomised. It is therefore probable that the effect is produced by an 

 excitation of the thyroid gland as the result of the administration. 



Effects of administering certain Hormonic Substances. 



Pilocarpine. 



For investigating the effects of pilocarpine two rats were taken, both 

 non-pregnant females (Xos. 92 and 93), weight respectively 140 grm. and 

 150 grm. Pilocarpine nitrate (0"006 grm.) in watery solution was injected 

 hypodermically. The animals were killed after five hours. 



Pancreas. — The alveoli appear small, and under a low power the 

 section looks compact. The alveolar cells are small. The cytoplasm 

 is less dense than usual, and shows no sharp distinction between inner 

 and outer zones. Some of the cells have small vacuoles. The nuclei, 

 of normal size, contain fine chromatin granules. The nucleoli, which 

 are not enlarged, are stained red by Mallory. There is no evidence 

 of mitosis. Zymogen is remarkably diminished, and is scattered in 

 the cytoplasm of the cells rather than being distinctly localised to 

 the outer zone. It is much more abundant in the alveoli immediately 

 surrounding the islets. The islet cells themselves are less dense in 

 appearance, but their nuclei and granules seem normal. In spite of 

 the intensive secretion which this dose of pilocarpine nitrate produces, 

 and the consequent changes in the quantity of zymogen granules, 

 there is no evidence of cell-division in the pancreas. 



Adrenalin. 



Two full-grown non-pregnant female rats (Nos. 94 and 95), weighing 

 respectively 210 grm. and 200 grm., were used for testing the effect of this 

 autacoid. To each animal was administered per diem 0"1 c.c. of a Parke, 

 Davis & Co.'s 1/1000 adrenalin solution along with their ordinary 

 food. They exhibited no special symptoms during the administration. 

 The appetite was not affected. The weight of the first rat was slightly 

 increased and that of the second slightly diminished at the end of the 

 experiment. 



Post-mortem there was nothing noteworth3^ 



Pancreas. — On microscopic examination of the pancreas the 

 alveoli and alveolar cells and their nuclei appear normal. The 

 cytoplasm appears to have shrunk more than usual in the pro- 

 cess of hardening, for around many of the nuclei a clear space is 



