Studies on the Endocrine Glands 305 



Fehlin^jj'.s and Xylander's tests, but no albumen. The rest showed neither 

 albumen nor glucose. 



Post-mortem none of the organs of these animals (which were 

 all fixed in 10 per cent, formol) showed a proper degree of firmness 

 after fixation, apparently owing to a swollen and cedematous con- 

 dition which can be noticed on microscopic examination to atiect the 

 cytoplasm of the cells. This applies not only to the pancreas but also 

 to the pituitary body, the pineal gland, the thyroid and parathyroid. 

 Otherwi.se there is nothing special to record, except that the zymogen 



Fig. 23. — Section of pancreas of rat (male) fed with an addition to its ordinary food of 

 dry posterior lobe of ox-pituitary. Microphotograph ; magnified 500 diameters. 

 Mallory's stain. 



The zymogen in the cells is comparatively lightly stained by the acid fuchsin, 

 and does not appear in the photograph in the form of black granules as in the 

 normal gland. Notice the swollen condition of the alveolar cells due to a 

 general vacuolation of their cytoplasm. 



granules in the alveolar cells of the pancreas stain less intensely than 

 normally with Mallory (fig. 2.3). 



Summary of Effects of Pituitary Feeding on the Pancreas 

 of the Rat. — Except that the zymogen granules appear to be more scanty 

 than usual, feeding with anterior lobe of pituitary body seems to produce 

 but little effect. Posterior lobe, on the other hand, causes swelling of the 

 cytoplasm of the cells. The zymogen granules in the pancreas are not 

 appreciably diminished in amount, but their character appears to be 

 somewhat altered, for the material does not stain so intensely red with 

 Mallory as is the case with the normal pancreas. The islets show no 

 particular alteration as a result of either anterior or posterior lobe feeding. 

 Feeding with anterior lobe has no effect upon the amount of urine, whereas 



