310 Kojima 



the thyroid-fed dog, owing to the greater diminution of zymogen 

 elsewhere. 



Summary. — Neither in the cat nor in the dog does thyroid feeding 

 appear to cause cell-multiplication in the pancreas ; at least no mitoses are 

 observable after several days' feeding, although in the rat they would be 

 very numerous. The most prominent effect of thyroid feeding is a diminu- 



FiG. 27. — Section of pancreas of dog (male) fed with an addition to its ordinary 

 diet of IS grni. of fresh sheep-thyroid i)er diem during ten days. Micro- 

 photograph ; magnified 400 diameters. Mallory's stain. 



This section is to be compared with the preceding one. It shows a 

 marked diminution in the amount of zymogen, the granules of which are 

 not so darkly stained by the acid fuchsin as in the normal preparation. 

 Some of the cells have very few granules. The nuclei are much more 

 apparent than in the normal, owing to the part of the cell which con- 

 tains them being free from zymogen. 



tion in the amount of zymogen in the alveolar cells. This applies to the 

 cat which received the thyroid decoction by subcutaneous injection as well 

 as to the animals which were fed by the mouth. 



Effect of Thyroid Feeding and Injection upon 

 Rabbits and Guinea-pigs. 



All the animals employed were full-grown males. 



Rabbit. — Two rabbits received the pressed-out juice of 7 or 8 grm. 

 of fresh sheep-thyroid per diem. For one of these (No. 1) the juice was 

 smeared over the cabbage leaves which were given along with oats for 

 fodder; in the other (No. 2) it was administered by means of a catheter 

 passed down the oesophagus into the stomach. After two or three days 

 the appetite in both was found to be considerably diminished, and in 

 No. 1 there was severe diarrhcea on the fourth day of the thyroid feeding. 

 Both animals became greatly emaciated, the weight considerably lessening. 

 Both died on the night of the fourth day. A third rabbit, which was 



