Studies on the Endocrine Glands 817 



the only one of these which seems to have the same effect as thyroid 

 administration is sodium iodide, which tends to cause similar morplio- 

 genetic changes in the pancreas, although of a less marked character. 

 It appears to act by stimulating the thyroid of the animal, for when 

 administered to rats which had previously been thyroidectomised, no effect 

 was observed. 



Effects of Hormonic Drugs and Autacoids upon the Pancreas. 



The effects of administering certain other substances which are known 

 to possess the property of exciting glandular structures, viz. pilocarpine, 

 adrenalin, and extracts of pituitary body, were also investigated. The 

 results obtained with these are described. They are entirely different from 

 those caused by thyroid feeding. 



Effects of Thyroid Feeding in Animals other than Rats. 



Experiments have been made to determine the results of thyroid feeding 

 in a number of animals besides the rat, viz. mouse, cat, dog, rabbit, guinea- 

 pig, and domestic fowl. Of these the mouse alone gives characteristic 

 karyokinetic appearances in the pancreas like those described in the rat. 

 In the cat, dog, rabbit, guinea-pig, and bird, mitoses have not been seen, 

 but in all the disappearance of zymogen granules from the alveolar cells 

 is marked. The general symptoms produced are similar to those seen 

 in the rat. In almost all animals the appetite decreases during the 

 administration. 



BIBLIOGRAPHY. 



(1) KojiMA, Proc. Roy. Soc. Edin., 1916, xxxvi. 240; Proc. Physiol. Soc. in 

 Journ. Physiol., 1916, vol. 1. p. xlv ; and Communication to the British Association 

 for the Advancement of Science, Xewcastle-on-Tyne, 1916 (unpublished). 



(2) Berkeley, Johns Hopkins Hosp. Bull., 1897, viii. 137. 



(3) Carlson, Rooks, and M'Kib, Amer. Journ. Physiol., 1912, xxx. 129. 



(4) Caldwell, Amer. Journ. Physiol., ibid., p. 42. 



(5) French, ibid., p. 30. 



(6) DoNALDSOxV, H. H., The Rat, 1915. 



(7) HosKiNS (a) Amer. Journ. Physiol., 1910, xxvi. 426-438; (b) Journ. of 

 Exper. Zool, 1916, xxi. 295-346. 



(8) Herring, this Journal, 1917, xi. 47; also Communication to the British 

 Association for the Advancement of Science, Ne\vcastle-on-Tyne, 1916 (unpublished). 



(9) Martin, Pharm. Journ. and Pharmacist, 1912, Ixxxix. 144. 



(10) Guyer, ibid., 1913, xci. 123. 



(11) Hutchison, Journ. Physiol., 1898, xxiii. 179. 



(12) Martindale and Westcott, The Extra Pharmacopoeia, 1915, ii. 134. 



(] 3) Babkin, Rubaschkin, and Ssawitsch, Arch. f. mikrosk. Anat., 1909, Ixxiv. 68. 



