STUDIES ON THE EXDUCHIXE GLANDS:— II.: THE RELA- 

 TIONS OF THE PITUITARY BODY WITH TIH-: THYROID 

 AND PARATHYROID AND CERTAIN OTHER ENDOCRINE 

 ORGANS IN THE RAT. By Masahahu Kojima, Fleet Surgeon, 

 Imperial Japanese Navy. (From the Physiology Department of 

 Edinburgh University.) (\Vith thirteen figures in the text and 

 one coloured plate.) 



{Received for jnihlication \st December 1916.) 



CONTENTS. 



Previous Observations ..... 

 Present Investigations ..... 

 Microscopic appearance.* of pituitary of rat 

 Effects of thyroidectomy in rat . 

 ,, parathyroidectomy in rat 

 ., castration in the male rat . 



feeding rats with tiiyroid and parathyroid . 

 ,, feeding rats with anterior lobe of ox-pituitary 

 ,. feeding rats with posterior lobe of ox-pituitary 

 ,, adrenalin administration in rat 

 „ sodium and potassium iodides in rat 

 Summary of observations on the rat 

 Microscopic appearances of pituitary of dog 

 Effects of partial thyroidectomy in dog . 



,, „ parathyroidectomy in dog 



Summary of observations on the dog 

 Bibliography .... 



Previous Observations. 



FAGE 

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The present paper includes a study of the effects of thyroidectomy, para- 

 thyroidectomy, and of castration on the pituitary body of the rat, and of 

 partial thyroidectomy and parathyroidectomy on the pituitary of the doer. 

 The effects of additions of thyroid, parathyroid, and pituitary body to the 

 food were also investigated in the rat. 



Thyroidectomy. — Rogowitsch (1) was the first to examine the effect 

 of thyroidectomy upon the pituitary. He has been followed by a number 

 of other investigators, but their results are not in accordance. Most ao-ree 

 that the whole gland enlarges and increases in weight. Rogowitsch de- 

 scribed the appearance of vesicles containing colloid in the pars anterior. 

 His observations were confirmed for cases of myxcedema in the human 

 subject by Schonemann (2), Boyce and Beadles (3), and others. Stieda 

 (4) described the occurrence of enlargement of the so-called principal or 

 chromaphobe cells (i.e. those staining but slightly with hematoxylin), and 

 the appearance of vacuoles within them, whilst the chromaphil cells were 

 VOL, XI., NOS. 3 and 4. — 1917. 21 



