326 Kojima 



Some of these swollen cells appear to be undergoing degeneration, their 

 nuclei being stained only faintly or hardly at all by hematoxylin. Basiphil 

 cells are present in great number. Their cytoplasm is of an open char- 

 acter and vacuolated. It is possible that the swollen cells above mentioned 

 are formed by an alteration of some of these basiphil cells. 



A large number of the nuclei of the cells of the pars intermedia are 

 enlarged (to about 7-5fJi). The pars nervosa shows comparatively few 

 droplets of hyaline substance in its meshes. 



Effects of Castration in the Male Rat. 

 From twenty to tifty-seven days after castration considerable changes 

 are found in the pituitary body. The most marked effect is produced by the 



Fig. 6. — Section of jiars anterior of pituitary body of thyroidectomised male rat fed with 

 addition to its ordinary food of 1 grm. of dry ox-thyroid per diem during seven days. 

 Microphotograph ; magnified 500 diameters. Hi^ematoxylin-eosin preparation. 



Many nf the cells are greatly enlarged. Tliere is a considerable accumulation of 

 hyaline substance, apparently the result of a degeneration of the cytoplasm. There are 

 alsoanumber of vesicles similar to those shown in tig. -J as the result of thyroidectomy. 



appearance of a large number of swollen cells in the pars anterior (fig. 4). 

 They are especially abundant near the periphery. Their description agrees 

 generally with that of the swollen cells mentioned as the result of thyroid- 

 ectomy and parathyroidectomy, so far at any rate as the cytopla.sm is con- 

 cerned. But many of their nuclei are much larger, and also have a swollen 

 appearance: they measure from 5-7^i to 11/a. Moreover, the chromatin 

 granules of the nuclei, which are fine, are less distinctly stained by h^ema- 

 toxylin than tho.se of the other cells of the gland. These cells have an 



