830 Kojima 



enlarged. Their cytoplasm is compact : it is stained a deep red both by eosin 

 and by Mallor}^ (acid fuchsin). The nuclei of all kinds of cells present are 

 somewhat enlarged, measuring from 5/x to 6/a: they contain abundance of 

 chromatin. No distinctive changes are to be seen in the pars intermedia. 



Effects of Feeding Rats with Posterior Lobe of Ox-Pituitary. 



The addition of posterior lobe of ox-pituitary to the food produces striking 

 changes in the pituitary body of the rat (fig. 9). The whole of the gland 

 has a loose aspect. The pars anterior is characterised by the lai'ge number 

 of oxyphil cells in it. The cytoplasm of these cells is open and finely vacuo- 



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Fig. 9. — Section of pars anterior of pituitary body of a male rat which had been fed with 

 addition of 2 centigr. of dry ox-pituitary (]>osterior lobe) per diem during seven days. 

 Jlicrophotograph ; magiiiHed 500 diameters. Hrematoxylin-eosin pre{)aration. 



Notice the marked vacuolation of the cytoplasm of neaily all tlie cells, and the 

 appearance of spaces between them, probably due to cedema. There are also a 

 number of clear vesicles in the section. The nuclei do not appear enlarged. 



lated. It is stained deep red both by eosin and by Mallory. The basiphil 

 and chromaphobe cells are swollen and fineh' vacuolated. The nuclei of 

 all the cells .stain distinctly by hsematoxylin and by Mallory (blue). Most 

 of their chromatin granules are fine. The cells of the pars intermedia are 

 swollen. The pars posterior has a looser appearance, as if there were an 

 accumulation of fluid in the reticulum. Speaking generally, the cytoplasm of 

 all kinds of cells in the gland is swollen, the nuclei beino- but little altered. 



Effects of Adrenalin Administration in Rat. 

 After the addition of adrenalin to the food certain laro^e cells become 

 apparent in the pars anterior. These cells .stain faintly red with eosin 

 and deep blue with Mallory. Their cj^toplasm is openly reticular, and 



