336 Kojima 



Pituitary Body (figs. 12 and 13). — There is a large cystic cavity 

 in the pars anterior communicating with the intraglandular cleft and 

 containing a thin material which is stained faintly with eosin. The cavity 

 is surrounded by cells belonging to the pars anterior and pars intermedia. 

 Oxyphil cells are abundant in the pars anterior, especially in the most 

 posterior portion and periphery. Most of them resemble the oxyphil cells 

 of the normal gland, but some of their nuclei show shrinkage. Basiphil 

 cells and chromaphobe cells ai'e relatively few in number. 



A considerable number of cells are seen in the pars anterior, especially 

 in the most anterior portion (but scattered also in other portions), which 

 are many times larger than the ordinary cells of the gland. Even under 

 a low power these cells are very apparent : they vary, however, in size and 

 in shape. Their cytoplasm is open in appearance and finely granular. It 

 stains faintly by ha^matoxylin, and contains numerous vacuoles. Their 

 nuclei vary from 5/a to 11/x in diameter, and stain more faintly than those 

 of the other cells. In many places these swollen cells surround vesicles, 

 but there is no hyaline substance within these vesicles. 



Besides the large cyst in the pars anterior, other cysts are present, the 

 hyaline contents of all being stained faintly by hreraatoxylin. The sub- 

 stance has, however, a thinner appearance than the ordinary hyaline 

 masses of the normal gland. 



The pars intermedia is thickened. It contains many vesicles of vari- 

 able size, but most are larger than those normally found. They contain 

 hyaline substance. The thickened pars intermedia with its vesicles extends 

 here and there backwards into the pars nervosa. The hyaline droplets of 

 the pars nervosa are not noticeably increased in amount. 



Effects of Partial Parathyroidectomy in Dog. 



For this experiment another young male fox-terrier (weighing 6050 grm.) 

 was operated on, on the same day as the other dog. The two external 

 parathyroids and the right internal parathyroid, with small portion of 

 thyroid, were removed, the left internal only being left. Small pieces 

 of both lobes of the thyroid were cut away, the largest portion for the 

 sake of removing the right internal parathyroid (which was found on 

 microscopical examination, after cutting this part into sections). The 

 feeding and general circumstances of the experiment were similar to those 

 of the other dog (partial thyroidectomy). On killing the animal at the 

 end of the experiment (nine weeks) the weight was found increased to 

 6850 grm. The animal suffered somewhat from diarrhoea, but showed no 

 other adverse symptoms. 



Pituitary Body. — It is apparent even under a low power that all 

 parts of the gland are much looser in texture than normal. The capillaries 

 of the pars anterior are considerably dilated and full of blood. The oxyphil 

 cells are remarkably abundant in all portions, without being distinctly 



